The Princes Highway is closed in both directions due to a truck fire near Bingie Road, about 8km south on Moruya.
Emergency services are on site. It's understood the truck is carrying gas cylinders.
With no suitable diversions, vehicles are also being parked on site.
Motorists are advised to delay their trip until the highway reopens, and allow plenty of extra travel time.
For the latest traffic information, visit www.livetraffic.com.